objective(s):therapies with high levels of oxygen are commonly used in the management of critical care. however, prolonged exposure to hyperoxia can cause acute lung injury. although oxidative stress and inflammation are purported to play an important role in the pathogenesis of acute lung injury, the exact mechanisms are still less known in the hyperoxic acute lung injury (hali).   materials a...

objective(s): abnormal lung cell death including autophagy and apoptosis is the central feature in acute lung injury (ali). to identify the cellular mechanisms and the chronology by which different types of lung cell death are activated during lipopolysaccharide (lps)-induced ali, we decided to evaluate autophagy (by lc3-ii and autophagosome) and apoptosis (by caspase-3) at different time point...

background: many of the multiple traumatized patients who refer to the hospital need transfusion. transfusion-related acute lung injury (trali) is a serious clinical syndrome associated with the transfusion of plasma-containing blood components. in the article, we present a case of trali following transfusion of packed red blood cells case presentation: a 24 year old male referred to shahid beh...

background: we aimed to reveal the role of cd11b and hypoxia-inducible factors-1alpha (hif-1α) expressions on monocytes and alveolar macrophages of lung tissue, and the levels of serum surfactant protein-d (sp-d) in severe malaria-associated acute lung injury (ali). methods: the c57bl/6 mice were divided into control group, renal malaria group (inoculated with 10 6 plasmodium berghei anka), and...

background: vitamin d, especially its most active metabolite 1,25-dihydroxyvitamin d₃(vit d) is essential in regulating a wide variety of biologic processes, such as regulating mesangial cell activation. the objective of this study was to assess the histopathological changes of effectiveness of vit d as a protective agent against radiation induced lung injury. materials and methods: eighteen wi...

objective(s): to study the effect of cardiopulmonary bypass (cpb) on nuclear factor-kappa b (nf-кb) and cytokine expression and pulmonary function in dogs. materials and methods: twelve male mongrel dogs were divided into a methylprednisolone group (group m) and a control group (group c). all animals underwent aortic and right atrial catheterization under general anesthesia. changes in pulmonar...

Background: Vitamin D, especially its most active metabolite 1,25-dihydroxyvitamin D₃(Vit D) is essential in regulating a wide variety of biologic processes, such as regulating mesangial cell activation. The objective of this study was to assess the histopathological changes of effectiveness of Vit D as a protective agent against radiation induced lung injury. Materials and Methods: Eighteen Wi...

background: transfusion services rely on transfusion reaction reporting to provide patient care and protect the blood supply. unnecessary discontinuation of blood is a major wastage of scarce blood, as well as man, hours and funds. the aim of the present study was to describe the main characteristics of acute transfusion reactions reported in the 4 hospital of kermanshah university of medical s...

acute respiratory distress syndrome (ards) is a complex disorder of heterogeneous etiologies characterized by a consistent, recognizable pattern of lung injury and a potentially devastating form of acute inflammatory lung injury with a high short-term mortality rate and significant long-term consequences among survivors. recently, the new definition of ards has been published, and this definiti...

Objective(s):Therapies with high levels of oxygen are commonly used in the management of critical care. However, prolonged exposure to hyperoxia can cause acute lung injury. Although oxidative stress and inflammation are purported to play an important role in the pathogenesis of acute lung injury, the exact mechanisms are still less known in the hyperoxic acute lung injury (HALI).   Materials ...